Consortium

Partner Organisations

Consortium composition and exploitation of partners’ complementarities

In this consortium, partners who are experts in the best available imaging technologies and who are leading in biodegradable Mg based implants come together. By the combination of techniques and academic / non-academic background (µCT with fluorescence – MUG; CT/µCT with immunohistology – UiO - SCANCO; MRI/ PET – CNR-IFC; MRS – MHH, MRI.T; IR - OsloMet and USPA - VSI, surface analysis technologies – WUT and HZG, material development and biomedical approval – SYN, BRI.T; molecular biological – UGOT and biochemical approaches – CNR-IFC) MgSafe offers complementarity in the best possible way.

Multimodality and mole-cular imaging can only provide outstanding data quality when animal burden and well-being are balanced. MgSafe takes this into account under a translational perspective.

Adapted animal models offered by MUG, UGOT, UiO, MHH and CNR-IFC and optimised technical approaches provided by the different partners (MRI.T, SYN, VSI, SCANCO) guarantee synergistic effects. A preclinical observation of the same materials in a down-sized small animal (rat - MUG, UGOT, UiO, MHH, CNR-IFC) and a clinical observation of fully sized implants in the large model (sheep and phantom, MUG, SYN) within the same time period will use the full spectrum of in vivo CT imaging, combined with ex vivo high-resolution and molecular methods (HZG, SCANCO, WUT).

The participation of such a high number of industry partners confirms the importance of the research questions and the need for qualified researchers in this field. The companies provide the whole network with insights from an industrial point of view concerning guidelines, patient safety and risk management. In addition, the Partner Organisation BRI.T contributes with start-up experience which can serve as a role model for the ESRs who are willing to start their own enterprise.

The partners of MgSafe have already cooperated in other projects: e.g. MUG, HZG, MHH and SYN were members of the Virtual Institute MetBioMat, coordinated by R: Willumeit-Römer. MHH and MRI.T cooperated on MR developments, CNR-IFC and VSI have a long standing cooperation in optimization of imaging set ups, and UiO, UGOT and OsloMet worked together on implants and bone structure analysis.

 


HZG

Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH


Country: Germany
Dept./Division/Laboratory: Metallic Biomaterials
Scientist-in-Charge: Prof. Dr. R. Willumeit-Römer
Website: https://www.hzg.de/institutes_platforms/materials_research/metallic_biomaterials/index.php.en

General description
The Helmholtz-Zentrum Geesthacht Centre for Material- and Coastal Research is one of 18 members of the Helmholtz Association of German Research Centres, Germany’s largest science organisation. HZG is located in Geesthacht near Hamburg with branches in Teltow near Berlin and in Hamburg, with a total staff of approximately 950 employees.

Major HZG research platforms include the German Engineering Materials Science Centre (GEMS) and the Magnesium Innovation Centre (MagIC). Within the HZG Institute of Materials Research the Division “Metallic Biomaterials” (http://www.hzg.de/metallic_biomaterials) focuses on the development of new (biodegradable) metallic implant materials.

High-level training and education for PhD-students and post-docs play an important role at HZG, and is provided by numerous of its institute and department leaders, several of which being part-time affiliated to universities.

Role and Commitment of key persons (including supervisors)

  • Prof. Dr. Regine Willumeit-Römer, Director at Institute of Materials Research (Metallic Biomaterials), University lecturer since 1998, supervision of more than 30 PhD theses, project management, coordination, training, supervision / main supervisor for ESRs 10 & 11
  • Dr. Felix Beckmann, Group leader µ- and nanotomography (X-ray optics, SR imaging, HDRI, reconstruction techniques), supervision, training
  • Dr. Jörg Hammel beamline manager, supervision, training
  • Dr. Vasyl Haramus, senior scientist, supervision
  • Dr. Florian Wieland, scientist, supervision, training
  • Dr. Julian Moosmann, scientist, supervision, training
  • Dr. Katharina Philipp, project manager
  • Dr. Thorsten Fischer, PR officer, Chair of Dissemination Board, on demand

Key Research Facilities, Infrastructure and Equipment
HZG operates synchrotron beam lines at the PETRA III source (DESY in Hamburg).
Among them: High density and spatial resolution SRμCT micro- and nanotomography allowing for simultaneous analysis of biological hard- and soft tissue. Attenuation and phase contrast imaging mode as well as analysis of sample series (sample changing robot) are available as well as electron-induced X-ray emission spectroscopy (EIXE) combined with SRμCT. Moreover, scanning SAXS with a 250 x 350 nm beam size is available (Nanofocus Endstation).
In addition: equipment for Mg implant material production, characterisation, processing up to cell culture experiments.

Relevant publications
[1] J. Moosmann et al.: Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography. Proc. SPIE, Developments in X-Ray Tomography XI (2017) 10391-23.
[2] B. Zeller-Plumhoff et al.: Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time-lapse SRμCT. Materials and Corrosion (2017) 1-9.
[3] T. Zander et al.: The influence of hyaluronan on the structure of a DPPC—bilayer under high pressures. Colloids and Surfaces B: Biointerfaces 142 (2016) 230–238.
[4] D.C.F. Wieland et al.: Investigation of the inverse piezoelectric effect of trabecular bone on a micrometer length scale using synchrotron radiation. Acta Biomat 25 (2015) 339 – 346.
[5] M.N. Holme et al.: Complementary X-ray tomography techniques for histology-validated 3D imaging of soft and hard tissues using plaque-containing blood vessels as examples, Nature Protocols 9(6) (2014) 1401-1415.

 


CNR-IFC

Consiglio Nazionale delle Ricerche Istituto di Fisiologia Clinica


Country: Italy
Dept./Division/Laboratory: Institute of Clinical Physiology IFC
Scientist-in-Charge: Prof. Dr. L. Menichetti
Website: https://www.ifc.cnr.it/index.php/en/

General description
The Italian National Research Council Institute of Clinical Physiology is situated at Pisa. IFC operates in the context of the Department of Biomedicine and is the largest biomedical institute of CNR. CNR-IFC occupies a privileged position in research and higher education, integrating three universities, the largest CNR (National Research Council) Campus in Italy, an internationally recognised University Hospital, and the G. Monasterio Foundation for Public Health and Medical Research. CNR-IFC is reference site for EuroBioImaging (www.eurobioimaging.eu). CNR-IFC cooperates with the School of Advanced Studies Sant’Anna, which provides a number of highly competitive scholarships from different founding organizations (www.santannaschool.eu).

Role and Commitment of key persons (including supervisors)
Prof. Luca Menichetti is Contract Research Professor at the Department of Chemistry at the University of Pisa and Full researcher at CNR, where he established a Molecular Imaging Group devoted to the study of multimodal imaging and novel molecular imaging approaches in preclinical models. He created a joint research group with the Public Foundation CNR/Tuscany Region "G.Monasterio” (FTGM, Pisa, IT) to contribute to the area of molecular imaging. Prof. Luca Menichetti is actively involved in PhD, BSc-MSc training and teaches at the University of Pisa and Scuola Sant’Anna of Advanced Studies. Since 2013, LM is designated reference person for the European platform Eurobio-imaging at CNR-IFC.

Further key persons at CNR-IFC

  • Dr. Giuseppina Basta, a recognised expert in the field of biochemistry, immunological technology, molecular biology and bio-humoral markers in metabolic and inflammatory diseases, supervision, training
  • Dr. Claudia Kusmic, scientific Director of the laboratory of experimental pathology on the small animals, supervision, training
  • Eng. Francesco Faita, recognised expert of Computer Vision for biomedical Imaging, supervision, training
  • Prof. Daniele Panetta, contract professor at the University of Pisa, expert in the validation of new PET tracers and related CT imaging protocols, supervision, training.

Key Research Facilities, Infrastructure and Equipment
A large facility with small and large surgical and post-surgery rooms exists at site where small, medium and large animals can be handled safely. Chronic and acute experimental models are available to address customised research requirements. The imaging resources at CNR-IFC comprise: (Micro)PET/SPECT, (µ)CT, (µ)US, Laser Doppler, (µ)Ultrasound-Photoacoustic Imaging (µUS-PA), MR-Hyperpolarized Imaging (DNP), Repository of Imaging reporters, Radio/Chemistry laboratories, Cyclotron 16MeV, Cell and tissue labs (histology, biochemistry, biobank), Genomics and proteomics Laboratory at the state-of-the-art.

Relevant publications
[1] C. Avigo et al. Enhanced Photoacoustic Signal of Passion Fruit-Like Nanoarchitectures in a Biological Environment. The Journal of Physical Chemistry C 121(12) (2017) 6955-6961.
[2] A.Luchini et al. Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: Defining the structure and probing: In vivo applications Nanoscale 8(19) (2016)10078-10086.
[3] F. Ratto et al. A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging. Advanced Functional Materials 26(39) (2016) 7178-7185.
[4] G. Aquaro et al. Hyperpolarized 13C-magnetic resonance spectroscopy are we ready for metabolic imaging? Circulation: Cardiovascular Imaging 7(6) (2014) 854-856.
[5] L. Menichetti et al. MicroPET/CT imaging of αvβ3 integrin via a novel 68Ga-NOTA-RGD peptidemi-metic conjugate in rat myocardial infarction. European Journal of Nuclear Medicine and Molecular Imaging 40(8) (2013) 1265-1274.

 


MUG

Medizinische Universität Graz


Country: Austria
Dept./Division/Laboratory: Dpt. of orthopaedics and orthopaedic surgery
Scientist-in-Charge: Prof. Dr. A. Weinberg
Website: https://forschung.medunigraz.at/fodok/suchen.person_uebersicht?sprache_in=en&ansicht_in=&menue_id_in=101&id_in=1120914

General description
Sustainable health research is the central theme at the Medical University of Graz. The Austrian health university is characterised by sustainability in teaching, research and patient care with main focus on prevention and preservation of health. In parallel, the health university provides high-level patient care by training future doctors and nurses and research on innovative treatment methods and health-preserving measures. Not only do students gain from expert knowledge, so does the whole population. Postgraduate continuing education for doctors and other target groups completes the broad range of services.

Role and Commitment of key persons (including supervisors)

  • Assoz. Prof.in Priv.-Doz.in Dr.in med. Annelie-Martina Weinberg – Supervisor

  • Nicole Grün, PhD – Supervision of pre-clinical imaging, small animal studies and biology

  • Nicholas Donohue, PhD – Supervision of pre-clinical imaging and large animal studies

  • Assoz. Prof. Priv.-Doz. Dr. Tobias Madl - Supervision of SAXS and metabolic phenotyping

Key Research Facilities, Infrastructure and Equipment
The Medical University of Graz is connected to the general hospital in Graz and benefits of all existing infrastructure. Furthermore, the university has a clinical research centre, with clinical MR and CT as well as laboratory devices for in vivo µCT. T. Madl is expert in NMR-based metabolomics and SAXS. His group owns a 600 MHz NMR spectrometer for metabolomics and an in-house SAXS machine.

Relevant publications
[1] A. Myrissa et al.: Gadolinium accumulation in organs of Sprague-Dawley® rats after implantation of a biodegradable magnesium-gadolinium alloy. Acta Biomater 48 (2017) 521-529.
[2] S. Stryeck et al.: Integrative metabolomics as emerging tool to study autophagy regulation. Microb Cell 4(8) (2017) 240-258.
[3] K. Baron et al.: Time-Dependent Changes in T1 during Fracture Healing in Juvenile Rats: A Quantitative MR Approach. PLoS One 11(11) (2016) e0164284.
[4] A. Myrissa et al.: In vitro and in vivo comparison of binary Mg alloys and pure Mg. J Mat Sci Eng C 61 (2016) 865-74.
[5] J. Hofstetter et al.: High-Strength Low-Alloy (HSLA) Mg-Zn-Ca Alloys with Excellent Biodegradation Performance. JOM 66(4) (2014) 566-572.

 


UiO

Universitetet i Oslo


Country: Norway
Dept./Division/Laboratory: Dept. of Biomaterials
Scientist-in-Charge: Prof. Dr. H. Haugen
Website: http://www.uio.no/english/

General description
Founded in 1811, the University of Oslo (UiO) is the highest ranked institution of education and research in Norway. UiO has over 27,000 students and 7,000 employees and is ranked 67th of the World’s Top 100 universities. With five Nobel Prize Winners, UiO has a strong track record of pionee-ring research and scientific discovery. The university offers more than 800 courses at all levels, several PhD programs are taught in English. Since 2007, UiO has been awarded 250 research projects funded by EU FP7 and 49 projects in Horizon 2020. The department of Biomaterials has a multidisciplinary team of clinicians, material engineers and biochemist. The most important contribution to innovation is made through the education of degree candidates, excellent research, and the exchange of knowledge with important stakeholders in society.

Role and Commitment of key persons (including supervisors)

  • Prof. S. Petter Lyngstaadas, Biomaterials, animal models

  • Prof. Janne Reseland, Bone biology

  • Prof. Håvard Haugen, material chemistry

Key Research Facilities, Infrastructure and Equipment
Long standing expertise on animal science, animal handling, animal models and histology of bone. Close relation to the Institute of Veterinary Medicine ensures regular access to professional animal facilities, and researchers are experienced in several animal models for bone healing and implant performance in rats, rabbits and pigs. Fully equipped for any type of histology, histomorphometry or in situ Hybridisation. In addition to the basic laboratory equipment: Atomic Force Microscopy, Molecular force probing, Confocal microscopy, Atom absorbance, Molecular Imaging, Protein and peptide separation techniques, Cell culture, Molecular biology including real-time PCR. Molecular Imaging, Protein and peptide separation techniques, Cell culture, and Molecular biology including real-time PCR and Luminex are also available in this laboratory. Advanced equipment like Affymetrix micro arrays, Scanning and Transmission electron microscopy, Mass spectroscopy, Flow cytometry and a state of the art tabletop SEM equipped with EDX (TM-3030) for back scatter analysis up-to 30 000 magnifications, confocal microscope, slide scanner, multiple microscope are available. A SkyScan 1172 microCT and a SkyScan 1122 nanoCT scanner are existing at the Department.

Relevant publications
[1] S. Haugen et al.: Adiponectin prevents orthodontic tooth movement in rats. Archives of Oral Biology 83 (2017) 304- 311.
[2] G. Cama et al.: The role of new zinc incorporated monetite cements on osteogenic differentiation of human mesenchymal stem cells. Materials Science and Engineering C: Materials for Biological Applications 78 (2017) 485- 494.
[3] L. Rumian et al.: Ceramic scaffolds enriched with gentamicin loaded poly(lactide-co-glycolide) microparticles for prevention and treatment of bone tissue infections. Materials Science and Engineering C: Materials for Biological Applications 69 (2016) 856-64.
[4] A. Verket et al.: TiO2 scaffolds in peri-implant dehiscence defects: an experimental pilot study. Clin Oral Implants Res 27(10) (2016) 1200.
[5] S. Geissler S et al.: Effect of cathodic polarization on coating doxycycline on titanium surfaces. Materials science & engineering C, Materials for biological applications 63 (2016) 359
[6] R. Xing R et al.: Surface hydride on titanium by cathodic polarization promotes human gingival fibroblast growth. Journal of Biomedical Materials Research Part A, 102(5) (2014)1389-1398.

Innovation products: Osseospeed®, TiBrush®, Emdogain®, NuGel®, NuBione®, NuPep®, Labridabrush®

 


OsloMet

Oslo Metropolitan University


Country: Norway
Dept./Division/Laboratory: Faculty of Technology, Art and Design
Scientist-in-Charge: Assoc. Prof. Dr. P. Mirtaheri
Website: https://www.hioa.no/eng

General description
HiOA is now known as OsloMet – Oslo Metropolitan University. The Norwegian government has granted Oslo and Akershus University College of Applied Sciences (HiOA) university status. HiOA is now a University. From 12 January 2018 we officially became a university. Our new name is OsloMet – Oslo Metropolitan University. Our Norwegian name is OsloMet – storbyuniversitetet.

Oslo Metropolitan University (formerly called HiOA) is Norway’s third largest education institution, with approx. 20 000 students and 2 100 employees. OsloMet’s Faculty of Technology, Art and Design educates 11 % of Norway’s engineers, and has research activities in technology, engineering, art and design. The Faculty attaches great importance on setting up sound links between the educational system and the labour market, and works closely with large national and international companies and institutions to provide students with the theoretical and professional knowledge and skills to thrive in today’s labour market. In 2016, the Faculty opened a centre for digitalisation with focus on artificial intelligence, cyber security and big data together with the prominent Simula Research Laboratory. The Simula research laboratory is specialised in making mathematical models in particular for biological systems. Another priority area for OsloMet and Norwegian national research is health care technology, and projects , which touch the field of biomedical engineering. Recently, OsloMet has strategically focused on health technology solutions in particular sensor technology and optical measurements. In 2009, OsloMet built its first optical/NIRS laboratory. The lab became part of a laboratory network at OsloMet with motion analysis lab, which is a collaboration arena between the faculty of Health Sciences and faculty of Technology, Art and Design.

Role and Commitment of key persons (including supervisors)

  • Dr. Peyman Mirtaheri, Associate professor, main advisor, NIRS measurements, supervision, training

  • Dr. Terje Gjøvaag, Associate professor, co-advisor, microcirculation in tissue, supervision, training

  • Ms. Evin Guler, Msc, Technical engineer at optical/NIRS lab., supervision, training

  • Stig Nøra and Hallvard Lavoll, PR department, Dissemination Board

Key Research Facilities, Infrastructure and Equipment
Optical light sources, spectrometers, 3D printers (for plotting physical models), optical fibres to connect the probes, software licences for unscrabler, matlab and /or eigenvectors multivariate program for analysing the data, computers and offices for the ESRs to work in a quiet environment. On the more practical side, the Department of Human Resources and the Department of Facilities Management can assist in finding temporary housing for the recruited ESRs. OsloMet also offers introductory seminars for new international employees on the services and benefits OsloMet offers. OsloMet also can also offer guidance for international employees on a variety of topics in collaboration with Oslo Chamber of Commerce and Norwegian courses in collaboration with the University of Oslo.

Relevant publications
[1] P. Mirtaheri: Fibre optical technology for monitoring and diagnostic applications, Nanobiosensors for Personalized and Onsite Biomedical Diagnosis, Chapter 17 (2016) ISBN: 9781849199513. 650 s. IET Digital Library.
[2] M. Amini et al.: Near-Infrared Spectra in Buccal Tissue as a Marker for Detection of Hypoxia. Aerospace medicine and human performance, 87(5) (2016) 498-504.
[3] P. Mirtaheri et al.: Partial pressure of carbon dioxide in mechanical loaded tissue: The canary in the Cage singing in tune with the pressure ulcer mantra. Annals of Biomedical Engineering 43(2) (2015)336-347.
[4] M. Amini et al.: A Novel Design of an Optical Probe for Detecting Perfusion Changes in Buccal Tissue. Sensors Journal, IEEE 12 (2012) 1861-1867.
[5] P. Mirtaheri et al.: A new biomedical sensor for measuring PCO2, Physiol. Meas. 25 (2004) 421-436.

 


MHH

Medizinische Hochschule Hannover


Country: Germany
Dept./Division/Laboratory: Magnetic resonance Spectroscopy, MRS
Scientist-in-Charge: Dr. M. Meier
Website: https://www.mh-hannover.de/index.php?id=2&L=1

General description
The Preclinical Imaging Center at the Hannover Medical School is located in the central animal facility and offers support as a collaborating research unit.

Role and Commitment of key persons (including supervisors)

  • Dr. Martin Meier, Deputy Supervisor, Senior Scientist

  • Prof. Dr. André Bleich, Supervisor

  • Christian Bergen, Technician

  • Bettina Bandel, PR officer, Dissemination Board

Key Research Facilities, Infrastructure and Equipment
The Preclinical Imaging Center at MHH is equipped with 4 Labs specialised in different imaging moda-lities such as Bruker Pharmascan 70/16 MRI/MRS, Siemens INVEON µCT, Visualsonics Ultrasound Vevo2100 and Perkin Elmer FMT4000 Fluorescence Tomography. Furthermore, animals can be housed under different conditions in the vicinity of the imaging labs.

Relevant publications
[1] M. Meier et al.: Old dog, new tricks—Functional, non-destructive and quantifying MRI/MRS method-ology of bones and soft tissue in a rat model for degradable magnesium based implant. Magn Reson Mater Phy 30(1) (2017) 501-692.
[2] H. C. Breuer et al.: Multimodality imaging of blood–brain barrier impairment during epileptogenesis. Journal of Cerebral Blood Flow & Metabolism 37(6) (2016) 2049-2061.
[3] K. Hueper et al.: Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PLoS One. Sep 15 11(9): (2016) e0162705.
[4] S. V. Rojas et al.: Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure: Thoughts and Progress. Artificial Organs June 14 (2016) DOI: 10.1111/aor.12728
[5] W. Dreher, M. Meier: 1H NMR Spectroscopy in Inhomogeneous B0 Fields Using Localized Constant Time Spin Echo Correlation Spectroscopy (L-CT-SECSY); MAGMA 28(1) (2015) 301.

 


UGOT

Sahlgrenska Academy at University of Gothenburg / Sahlgrenska akademin Göteborgs universitet


Country: Sweden
Dept./Division/Laboratory: Department of Biomaterials
Scientist-in-Charge: Prof. Dr. P. Thomsen
Website: https://www.gu.se/English

General description
The University of Gothenburg is a comprehensive university, organised into eight faculties and more than 40 departments. The medical faculty (Sahlgrenska Academy) has six institutes in the fields of medicine, odontology and health care/sciences. The concentration of these institutes in one faculty promotes efficient interdisciplinary collaboration. Basic research conducted at the Sahlgrenska Aca-demy is of world class, and research findings conducted there have opened the way for several successful pharmaceuticals and medical devices, including the osseointegrated oral titanium implants (Professor P-I Brånemark). Hence, the biomaterials research area has a strong tradition and University of Gothenburg has recently been highlighted as the No 1 University globally in the field of osseointegration. The biomaterials research spans from materials across pre-clinical to clinical fields, particularly related to dental, orthopaedic and cardiovascular application areas. The Departments of Biomaterials and Experimental Biomedicine are major assets for experimental (animal) research, owning one of the most modern facilities in Northern Europe. The Department of Biomaterials is a partner in the Swedish Government Strategic funding Area of Advance in Materials Science, hosted by Chalmers University of Technology.

Role and Commitment of key persons (including supervisors)

  • Assoc. Prof. Anders Palmquist researcher, structural and morphological techniques ranging from macro to nanoscale tissue material interactions, special interest in osteocyte organisation and their infrastructure for mechanotransduction and remodelling, supervisor at UGOT for ESR 4
  • Dr. Omar Omar researcher, animal models and gene expression analysis, supervision, training
  • Prof. Dr. Peter Thomsen, MD, PhD, Head of the Department of Biomaterials, supervisor at UGOT for ESR 4 will contribute with his expertise in cell-material interactions. He will participate in the overall planning of the project, interpretation of results and manuscript writing. He will also contribute with the formulation of detailed plans for implementation and future strategies together with the other partner groups.

Key Research Facilities, Infrastructure and Equipment
UGOT has a long tradition in the field of osseointegration and bone healing around biomaterials. The department has developed several animal models for evaluation of different aspects of biomaterials, covering different bone types and soft tissues. In recent years, particular emphasis has been on the development of toolboxes and in vivo sample preparation techniques to assess molecular events and structural and compositional aspects during the sequential stages of inflammation, bone formation and remodelling. The expertise ranges from experimental animal, via sample preparation to analysis using state of the art, qPCR, histology, immunohistochemisty, electron microscopy and spectroscopic techniques. The department has a cell culture facility, and a microbiology laboratory devoted to studies on interactions between microorganisms, host defence and material surfaces.

Relevant publications
[1] F.A. Shah et al.: Micrometre-sized magnesium whitlockite crystals in micropetrosis of bisphosphonate-exposed human alveolar bone. Nano Letters 17 (2017) 6210-6216
[2] F.A. Shah et al.: 3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface. Acta Biomater 30 (2016) 357-367.
[3] Lennerås et al.: Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving RANK/RANKL/OPG Regulation. Clin Implant Dent Relat Res 17 (2015) 486-500.
[4] F. A. Shah et al.: High-resolution visualisation of the osteocyte lacuno-canalicular network juxtaposed to the surface of nanotextured titanium implants in human. ACS Biomater Sci Eng 1 (2015) 305-313.
[5] S. Svensson et al: A novel soft tissue model for biomaterial-associated infection and inflammation – Bacteriological, morphological and molecular observations. Biomaterials 41 (2015) 106-121.

 


WUT

Warsaw University of Technology - Politechnika Warszawski


Country: Poland
Dept./Division/Laboratory: Faculty of Materials Science and Engineering
Scientist-in-Charge: Prof. W. Swieszowski
Website: http://www.materials.pl/home.php

General description
The Warsaw University of Technology is the largest and ranked the number “one” among 18 technical universities in Poland. In the academic year 2013, more than 32,000 students were registered at three-level studies – B.Sc., M.Sc., and over 1,300 PhD. students. WUT is the most important scientific centre of engineering in Poland with internationally recognized prestige. WUT is a university with 17 faculties. The Faculty of Materials Science and Engineering (FMSE) is the leading research and higher education institution in Poland (possessing A+ category awarded in the Science Evaluation Exercise of the Ministry of Science and Higher Education). FMSE combines a strong interest in new materials and technologies with significant achievements in applied science. Main research topics include: materials characterization and modelling; design and processing of nano-materials; failure and degradation of engineering materials; materials for bio-applications and alternative energy. Research is funded by the National Research Funding Agencies, the EC and industry. Faculty permanent staff: ~80 persons, ~100 PhD students.

Role and Commitment of key persons (including supervisors)

  • Prof. Wojciech Swieszkowski, Supervisor, expert in the field of biomaterials, including biomaterial synthesis, characterisation and modelling, smart biomaterials for tissue regeneration, drug delivery, biofabrication, training, supervision
  • Dr. Tomasz Plocinski, Co-supervisor, expert in HR SEM/TEM/FIB techniques, training, supervision

Key Research Facilities, Infrastructure and Equipment
Nano- and micro- structure TEM (Jeol JEM 3010), STEM (Hitachi HD 2700 with Cs correction system and Hitachi S 5500), X-ray Micro/Nano Tomography and Focus Ion Beam, Confocal Microscope – Leica TCS SP8), 3D architecture (Nano and micro CT), chemical composition (FTIR, Raman microscopy, EDS, XPS, Auger, DSC, GPC, TGA), mechanical properties (Zwick, MTS, ElectroForce 5100 BioDynamic Test Instruments, Hysitron, AFM etc), and surface (profilometer, AFM, Contact Angle System OCA).

Relevant publications
[1] Witecka et al.: Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloy. Colloids Surf B Biointerfaces 144 (2016) 284-292.
[2] J. Witkowska et al.: Hybrid a-CNH+TiO2+TiN-type surface layers produced on NiTi shape memory alloy for cardiovascular applications. Nanomedicine 12(18) (2017) 2233-2244.
[3] J. Witkowska et al.: Corrosion resistance of NiTi shape memory alloy after hybrid surface treatment using low-temperature plasma. Vacuum 137 (2017) 92-96.
[4] R. Sitek et al.: Microstructure and oxidation resistance of aluminide layer produced on Inconel 100 nickel alloy by CVD method. Surface and Coatings Technology 304 (2016) 584-591.
[5] M. Tacikowski et al.: Composite titanium nitride layers produced on the AZ91D magnesium alloy by a hybrid method including hydrothermal modification of the layer. Applied Surface Science 346 (2015) 394-405.

 


MRI.T

MRITools GmbH


Country: Germany
Scientist-in-Charge: Prof. Dr. T. Niendorf
Website: http://mritools.de/

General description
MRI.TOOLS GmbH (Berlin, Germany, www.mritools.de) is an SME that designs, develops, manufactures and delivers solutions for clinical and preclinical biomedical imaging to meet the needs of the ever growing market of medical technology. MRI.TOOLS’s main focus is on research & development, sales and services of innovative hardware and novel technology for magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET). MRI.TOOLS’ product portfolio encompasses enabling radiofrequency (RF) antennae tailored for a broad range of MR applications. MRI.TOOLS is also very proud to offer services for MR compatibility tests, MR safety validation and certification of medical devices and passive conductive implants. For this purpose MRITOOLS builds on more than 25 personnel years of experience in MRI science and industry.

Role and Commitment of key persons (including supervisors)

  • Prof. Dr. Thoralf Niendorf is CEO of MRI.TOOLS GmbH and Professor/Chair for Experimental Ultrahigh Field Magnetic Resonance at the Charité - University Medicine, Berlin, Germany.
    He has been working in the field of MRI and (pre)clinical imaging for over 25 years. His expertise is formed around novel technology and methodology for (ultrahigh field) MRI to advance the capabilities of biomedical imaging. This includes his research into MR safety and the physics governing RF induced heating of conductive implants. He will devote to the supervision of ESR 13 and training.
  • Dr. Helmar Waiczies is CSO of MRI.TOOLS GmbH. After gaining major research experience in the field of MRI he has been responsible for R&D, product development and certification for more than 10 years. His research activities regard the development of RF coils tailored for (pre)clinical imaging. He has major experience in project management including internationally FP7 (INSERT-FP7, heart4EU-EUROSTARS) and nationally funded (NAMRIS-BMBF, THERAHEAT-BMBF) projects. He will supervise and train ESR 13 and participate in the Dissemination Board.

Key Research Facilities, Infrastructure and Equipment
MRI.TOOLS is equipped with all the tools required for safety assessment of conductive implants includ-ing electromagnetic field simulations, E-field measurements, MR thermometry and fibre optic temper-ature measurements. The MRI.TOOLS lab accommodates all infrastructure needed for RF coil and MR applications development, testing and production, which provides an excellent base for training and supervising early stage researchers. Pay-per-use access to small bore and human MR scanners is avail-able.

Relevant publications
[1] E. Oberacker et al.: Magnetic resonance safety and compatibility of tantalum markers used in proton beam therapy for intraocular tumors: A 7.0 Tesla study. Magnetic Resonance in Medicine 78 (2017) 1533-46.
[2] L. Winter et al.: Magnetic resonance thermometry: Methodology, pitfalls and practical solutions. Int J Hyperthermia 32(1) (2016) 63-75.
[3] L. Winter et al.: On the RF heating of coronary stents at 7.0 Tesla MRI. Magnetic Resonance in Medicine 74(4) (2015) 999-1010.
[4] C. Oezerdem et al.: 16-channel bow tie antenna transceiver array for cardiac MR at 7.0 tesla. Magn Reson Med 75(6) (2015) 2553-2565.
[5] A. Graessl et al.: Modular 32-channel transceiver coil array for cardiac MRI at 7.0T. Magn Reson Med 72 (2014) 276-290.

Innovation product: easyACT: acoustic cardiac triggering device for synchronization of MRI with cardiac activity (CE certified)

 


SYN

Syntellix AG


Country: Germany
Scientist-in-Charge: Dr. J.-M. Seitz
Website: http://www.syntellix.de/en

General description
Research, development and marketing of highly innovative bioabsorbable metallic implants made of magnesium alloys. Syntellix supervises a competence network with partners from material sciences, manufacturing, cleaning, packaging and clinical application, knowledge in the implant development and especially in the certification processes and regulatory limitations of (Mg-) implants.

Role and Commitment of key persons (including supervisors)

  • Dr. J.-M. Seitz, engineer, materials science, production technologies, quality management, regulatory affairs, advice to the PhD-student.
  • Dr. K. Nagel, engineer, biomedical testing, regulatory affairs, advice to the PhD-student, supports analyses and evaluation of tests and their results
  • P. Frega, Marketing expert, Dissemination Board.

Key Research Facilities, Infrastructure and Equipment
Syntellix will provide Mg-based implants, which are approved for clinical use in Europe. Syntellix will furthermore provide space for sample preparation and an environment for some of the analyses that have to be conducted. Workspace for CAD and minor simulations is provided.

Relevant publications
[1] H. Naujokat et al.: Osteosynthesis of a cranio-osteplasty with a biodegradable magnesium plate system in miniature pigs. Acta Biomater 62 (2017) 434.
[2] E. Willbold et al.: Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval-related considerations. J. Biomed. Mater. Res. Part A 105(1) (2017) 329-347.
[3] J.S:Seitz et al.: Magnesium-Based Compression Screws: A Novelty in the Clinical Use of Implants. JOM 68 (2016) 1177.
[4] H. Waizy et al.: In vivo study of a biodegradable orthopedic screw (MgYREZr-alloy) in a rabbit model for up to 12 months. J. Biom. App. 28 (2014) 667–75.
[5] M. Ezechieli et al: Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo. J Biomater Appl 29 (2014) 291-302.

 


SCANCO

Scanco Medical AG


Country: Switzerland
Scientist-in-Charge: Dr. V. Stadelmann
Website: http://www.scanco.ch/

General description
The Swiss company SCANCO Medical AG has been a pioneer in the field of high-resolution micro-computed tomography (microCT) for more than two decades. Starting with the first installation in Swit-zerland in1988, the systems for medical and industrial applications are now operating on six conti-nents. In addition to the hardware, SCANCO Medical AG also provides software for image analysis, measurement service and consulting in the field of bone research in pre-clinical and clinical studies. The many collaborations and involvement in research projects lead to an accumulation of in-depth knowledge that is highly valued by the customers.

Role and Commitment of key persons (including supervisors)

  • Dr. Vincent Stadelmann expert in micro-computed tomography and preclinical imaging. Main supervisor at SCANCO.
  • Dr. Bruno Koller, CEO of SCANCO Medical AG for more than 25 years. Supervision.

Key Research Facilities, Infrastructure and Equipment
Scanco Medical AG offers three microCT system classes; in vitro systems for bone and material re-search, small animal systems for pre-clinical studies and high-resolution clinical systems for the as-sessment of bone density and structure in human extremities. Where the in vitro and small animal system mainly address the pre-clinical research market, the clinical systems may become a new stand-ard in osteoporosis diagnosis and have the potential to not only cover clinical research but may also be used in clinical routine and thus enter the clinical market.

Relevant publications
[1] V. A. Stadelmann et al.: In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model. BioMed Research International (2015) 587857.
[2] K. Becker et al.: Automated 3D-2D registration of X-ray microcomputed tomography with histological sections for dental implants in bone using chamfer matching and simulated annealing. Comput Med Imaging Graph 44 (2015) 62-8.
[3] F. Schulte et al.: Image interpolation allows accurate quantitative bone morphometry in registered micro-computed tomography scans. Comput Methods Biomech Biomed Engin 17(5) (2014) 539-48.
[4] G. Sengle et al.: A Correlative Method for Imaging Identical Regions of Samples by Micro-CT, Light Microscopy, and Electron Microscopy Imaging Adipose Tissue in a Model System. J Histochem Cytochem 61(4) (2013) 263-71
[5] V. A. Stadelmann and Potapova, I.: Non-invasive biomechanical assessment of implant fixation with in-vivo computed tomography: Perspectives for infected implants. European Cells and Materials 21(2) (2011).

 


VSI

FujiFilm Sonosite B.V


Country: Netherlands
Scientist-in-Charge: Dr. J. Jose
Website: https://www.visualsonics.com/

General description
Fujifilm Sonosite (formerly known as Fujifilm VisualSonics) is the world leader in real time, in vivo, imaging systems, designed specifically for preclinical research. VSI high-frequency micro-imaging plat-forms combine high-resolution, real-time in vivo imaging with quantifiable data that have been pub-lished in over 900 scientific publications globally.

Conventional ultrasound systems used in human (or clinical) applications operate in the 3–15 MHz frequency range, providing spatial resolution down to 300 micrometers and penetrate to a depth of 8 centimeters. These specifications are sufficient to image human organs. Conversely, when imaging a small animal such as a mouse, much higher resolution is necessary to provide useful images while depth of penetration is not required. Trading off depth penetration for higher resolution, VSI technol-ogy enable imaging down to 30 µm for depths of 3 centimeters. In addition to high-frequency ultra-sound, VSI launched a Photoacoustic Imaging platform which combines high-resolution ultrasound with the specificity of optical imaging. Photoacoustics is a non-ionizing, functional imaging modality, capable of generating high contrast images of optical absorption at depths significantly greater than traditional optical imaging techniques.

Visualsonics is an innovative company, looking to explore the preclinical and clinical imaging market with new and ground-breaking imaging approaches.

Role and Commitment of key persons (including supervisors)

  • Several research and development activities were carried out in the Visualsonics laboratory located in Amsterdam and Dr. Jithin Jose is responsible for the research and development activities in the VSI laboratory in Amsterdam. He also coordinates the ongoing scientific projects in collaboration with different European research groups. He is the co-author of more than 14 refereed journal publications and maintains active research interest in the applications of photoacoustic imaging in pre-clinical and clinical practice.
  • Dr. Jithin Jose will focus on the project management, coordination and be the main supervisor at VSI.
  • Dr. Magdalena Steiner, Sales Manager, training and supervision.

Key Research Facilities, Infrastructure and Equipment
VSI has its European headquarters in The Netherlands with 16 employees. A fully equipped laboratory is also based in Amsterdam. Two Ultrasound (Vevo 3100, Vevo 2100) and 2 Photoacoustic (Vevo LAZR-X, Vevo LAZR) imaging systems are available in the facility for training and advanced R&D projects.

Relevant publications
[1] N. Beztsinna et al.: Photoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers. Int J Nanomedicine. 12 (2017) 3813-3825.
[2] A.M. Yashchenoket al.: Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood. J Biophotonics 9(8) (2016) 792-799.
[3] M. Petri et al.: Photoacoustic imaging of real-time oxygen changes in chronic leg ulcers after topical application of a haemoglobin spray: a pilot study. J Wound Care 25(2) (2016) 87-91.
[4] M. Prato et al.: 2H,3H-Decafluoropentane-Based Nanodroplets: New Perspectives for Oxygen Delivery to Hypoxic Cutaneous Tissues. PLoS ONE 10(3) (2015) e0119769.
[5] M. Lakshman, A. Needles: Screening and quantification of the tumor microenvironment with micro-ultrasound and photoacoustic imaging. Nat. Publ. Gr. 12 (2015).

 

 

 


BRI.T

BRI.Tech – BioResorbable Implant Technologies


Country: Austria
Scientist-in-Charge: Dr. J. Eichler
Website: http://britech.eu/

General description
BRI.Tech GmbH orthopaedic implants are used for the surgical treatment of bone fractures. Our im-plants are made of a patented magnesium-based alloy which dissolves over time during the healing process. The focus is on CE Certification, market entrance and coordination of further R&D activities. A quality management system is currently developed according to ISO13485 which is an essential part for the certification process. The supply chain of BRI.T is already present with ISO13485 certified part-ners. Distribution will be outsourced (ideally to an experienced strategic partner).

Role and Commitment of key persons (including supervisors)

  • Ing. Hein Moitzi, Co-Founder and technical advisor, production, research and development, quality control, environment, safety, maintenance, and procurement.
  • Dr. Nicole Grün: Supervision of pre-clinical imaging and animal surgery, supervision of processing and prototype implants, training.

Key Research Facilities, Infrastructure and Equipment
BRI.T provides a fully equipped office as well as an R&D lab with basic equipment. Headquarter is in Graz, closely connected to the Medical University of Graz (MUG). As a spin-off company of the Medical University, it benefits of all existing infrastructure of the MUG.

Relevant publications
[1] J. Eichler et al.: Adhesive strength of bone-implant interfaces and in-vivo degradation of PHB composites for load-bearing applications. Journal of the Mechanical Behavior of Biomedical Materials. 53 (2016) 104–118.
[2] F. Amerstorfer et al.: Long-term in vivo degradation behavior and near-implant distribution of resorbed elements for magnesium alloys WZ21 and ZX50. Acta Biomaterialia 42 (2016) 440–450.

Innovation Product: BRI.MAG ®, a ternary alloy composed of Magnesium, Calcium and Zinc (Patent: PCT/EP2014/071255)